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Anti-EPO Receptor (Tyr368), ALEXA Fluor 594

  • Catalog number
    GENTObs-13087R-A594
  • Product name
    Anti-EPO Receptor (Tyr368), ALEXA Fluor 594
  • Size
    100 microliters
  • Short name
    Anti-EPO Receptor (Tyr368)
  • Type
    Conjugated Primary Antibody
  • Conjugated with
    ALEXA FLUOR® 594
  • Host organism
    Rabbit (Oryctolagus cuniculus)
  • Target Protein Peptide
    EPO Receptor Tyr368
  • Specificity
    This antibody reacts specifically with EPO Receptor (Tyr368)
  • Modification
    Phosphorylation
  • Modification site
    Tyr368
  • Clonality
    Polyclonal Antibody
  • Clone
    Polyclonal Antibodies
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Subcellular locations
    N/A
  • Antigen Source
    KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
  • Gene ID
    2057
  • Swiss Prot
    N/A
  • Applications
    IF(IHC-P)
  • Applications with corresponding dilutions
    IF(IHC-P)(1:50-200)
  • Cross reactive species
    Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
  • Cross Reactive Species details
    No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information
    The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
  • Purification method
    Purified by Protein A.
  • Storage
    Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Excitation emission
    590nm/617nm
  • Synonyms
    EPO Receptor phospho Y368; p-EPO Receptor phospho Y368; EPOR phospho Y368; p-EPOR phospho Y368; erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
  • Also known as
    EPO Receptor (Tyr368) Antibody
  • Other name
    Anti-EPO Receptor (Tyr368)
  • Advisory
    Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Alternative to gene target
    • [ "erythropoietin", "EP and MVCD2", "EPO and IDBG-31941 and ENSG00000130427 and 2056", "protein kinase activator activity", "Extracellular", "Epo and IDBG-205003 and ENSMUSG00000029711 and 13856", "EPO and IDBG-640493 and ENSBTAG00000003430 and 280784" ]
  • Gene target
    EPO Receptor Tyr368
    • Gene info
    Gene info
    Locus Specific Databases:Global Variome shared LOVD
    Gene info
  • Gene symbol
    EPO, TIMP1, EPX
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 594
  • label filter
    • ALEXA FLUOR 594
  • technique filter
    • anti-
    • anti
  • Technique
    anti-, anti, antibody to, antibodies
  • Alternative technique
    antibodies