gentaur logogentaur logo
x

Anti-EPHA2 (Polyclonal), HRP

  • Catalog number
    GENTObs-10209R-HRP
  • Product name
    Anti-EPHA2 (Polyclonal), HRP
  • Size
    100 microliters
  • Short name
    Anti-EPHA2 HRP
  • Type
    Conjugated Primary Antibody
  • Conjugated with
    HRP
  • Host organism
    Rabbit (Oryctolagus cuniculus)
  • Target Protein Peptide
    EPHA2
  • Specificity
    This antibody reacts specifically with EPHA2 HRP
  • Modification
    No modification has been applied to this antibody
  • Modification site
    None
  • Clonality
    Polyclonal Antibody
  • Clone
    Polyclonal Antibodies
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Subcellular locations
    Extracellular
  • Antigen Source
    KLH conjugated synthetic peptide derived from human EPHA2
  • Gene ID
    1969
  • Swiss Prot
    P29317
  • Applications
    IHC-P
  • Applications with corresponding dilutions
    IHC-P(1:100-500)
  • Cross reactive species
    Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
  • Cross Reactive Species details
    No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information
    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
  • Purification method
    Purified by Protein A.
  • Storage
    Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
  • Excitation emission
    N/A
  • Synonyms
    ECK; CTPA; ARCC2; CTPP1; CTRCT6; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2
  • Also known as
    EPHA2 Polyclonal Antibody HRP
  • Other name
    Anti-EPHA2 Polyclonal HRP
  • Advisory
    Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Alternative to gene target
    • [ "EPH receptor A2", "ARCC2 and CTPA and CTPP1 and CTRCT6 and ECK", "EPHA2 and IDBG-91407 and ENSG00000142627 and 1969", "transferase activity", "Cell surfaces", "Epha2 and IDBG-202005 and ENSMUSG00000006445 and 13836", "EPHA2 and IDBG-645870 and ENSBTAG00000000815 and 512798" ]
  • Gene target
    EPHA2
    • Gene info
    Gene info
    • Identity:HGNC:40216
    • Gene:EPHA2-AS1
    • Long gene name:EPHA2 antisense RNA 1
    • Discovery year:2021-07-29
    • Entrez gene record:101927479
    • Classification:Antisense RNAs
  • Gene symbol
    EPHA2, EPHA2-AS1
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    HRP
  • label filter
    • HRP
  • technique filter
    • Polyclonal
    • anti-
    • anti
  • Technique
    Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Alternative technique
    polyclonals, antibodies