MK2 Inhibitor III

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Stock availability

In Stock
Cas number

724711-21-1
Chemical s molecular weight

340.38
Chemical s main applications

MK2 Inhibitor III is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis.
Chemical s category

Amines, Aromatics, Heterocycles, Inhibitors, Protein Kinase Inhibitors and Activators
Other name

1,5,6,7-Tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one
Chemical s formula

C21H16N4O
Physical properties

Off-White to Pale Yellow Solid
Melting temperature

>255°C (dec.)
Boiling temperature

No Data Available
Chemical s soluble in

DMSO
Stability conditions

No Data Available
Storage

Refrigerator
Chemical s specifications
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

MK2 Inhibitor III
Gene symbol

MAPKAPK2, CPLX3, MGAT3, MGST3, P4HA3, CASP5, THAP4, IGHVIII-82, MT-CSB3, IGHVIII-67-4
Short name

MK2 Inhibitor III
Alternative name

MK2 suppressor III

Identity

HGNC:6887
Gene

MAPKAPK2
Long gene name

MAPK activated protein kinase 2
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 2
Synonyms
- MK2
GenBank acession
- U12779
Locus

1q32.1
Discovery year

1999-03-26
Entrez gene record

9261
Pubmed identfication
- 8179591
- 8280084
RefSeq identity
- NM_004759
Classification
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000036342

Identity

HGNC:7046
Gene

MGAT3
Long gene name

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms gene name
- mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Synonyms
- GNT-III
GenBank acession
- D13789
Locus

22q13.1
Discovery year

1993-08-27
Entrez gene record

4248
Pubmed identfication
- 8370666
RefSeq identity
- NM_002409
Classification
- Mannosyl-glycoprotein N-acetylglucosaminyltransferases
VEGA ID

OTTHUMG00000030185

Identity

HGNC:30135
Gene

P4HA3
Long gene name

prolyl 4-hydroxylase subunit alpha 3
Synonyms gene name
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
- prolyl 4-hydroxylase, alpha polypeptide III
Synonyms
- C-P4Halpha(III)
Synonyms name
- collagen prolyl 4-hydroxylase alpha(III)
GenBank acession
- AY327887
Locus

11q13.4
Discovery year

2004-05-12
Entrez gene record

283208
Pubmed identfication
- 14500733
RefSeq identity
- NM_182904
VEGA ID

OTTHUMG00000165254

Identity

HGNC:1506
Gene

CASP5
Long gene name

caspase 5
Synonyms gene name
- caspase 5, apoptosis-related cysteine protease
- caspase 5, apoptosis-related cysteine peptidase
Synonyms
- ICE(rel)III
Locus

11q22.3
Discovery year

1996-09-13
Entrez gene record

838
Pubmed identfication
- 7797592
- 9250871
RefSeq identity
- NM_004347
Classification
- Caspases
- Caspase recruitment domain containing
VEGA ID

OTTHUMG00000048073

Identity

HGNC:5709
Gene

IGHVIII-82
Long gene name

immunoglobulin heavy variable (III)-82 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (III)-82
- immunoglobulin heavy variable (III)-82 pseudogene
Synonyms
- IGHV(III)-82
GenBank acession
- AB019437
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28338
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000151732

Identity

HGNC:5707
Gene

IGHVIII-67-4
Long gene name

immunoglobulin heavy variable (III)-67-4 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (III)-67-4
- immunoglobulin heavy variable (III)-67-4 pseudogene
Synonyms
- IGHV(III)-67-4
GenBank acession
- AB019437
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28340
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000151874