Descyclopropyl Abacavir

  • Catalog number
    D288865
  • Price
    Please ask
  • Size
    1 mg
  • Chemical available in other sizes
    Please inquire size and price
  • Stock availability
    In Stock
  • Cas number
    124752-25-6
  • Chemical s molecular weight
    246.27
  • Chemical s main applications
    Descyclopropyl Abacavir is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
  • Chemical s category
    Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
  • Other name
    (1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentene-1-methanol; USP Abacavir Related Compound A
  • Chemical s formula
    C11H14N6O
  • Physical properties
    Off-White to Pale Yellow Solid
  • Melting temperature
    177-179ºC
  • Boiling temperature
    No Data Available
  • Chemical s soluble in
    DMSO (Slightly), Methanol (Slightly, Heated)
  • Stability conditions
    No Data Available
  • Storage
    -20˚C Freezer
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