3-O-Methyl Fulvestrant

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Cas number

1221256-46-7
Chemical s molecular weight

620.8
Chemical s main applications

3-O-Methyl Fulvestrant, is a derivative of Fulvestrant (F862502), a novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).
Chemical s category

Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids, Sulfur & Selenium Compounds
Other name

(7α,17β)-3-methoxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-17-ol;
Chemical s formula

C33H49F5O3S
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications
Description

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3. In formulas, the group is often abbreviated Me. Such hydrocarbon groups occur in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, it can be found on its own in any of three forms anion, cation or radical. The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed,

Gene target

3-O-Methyl Fulvestrant
Gene symbol

CENPO, H4C15, POFUT1, SDR9C7, GNAO1, H3C15, FABP3, H2BC19P, MIR1302-3, MIR509-3
Short name

3-O-Methyl Fulvestrant
Alternative name

3-O-Methyl Fulvestrant

Identity

HGNC:29607
Gene

H4C15
Long gene name

H4 clustered histone 15
Synonyms gene
- HIST2H4B
Synonyms gene name
- histone 2, H4b
- histone cluster 2, H4b
- histone cluster 2 H4 family member b
Synonyms
- H4/o
GenBank acession
- BC108260
Locus

1q21.2
Discovery year

2006-06-12
Entrez gene record

554313
Pubmed identfication
- 15527963
RefSeq identity
- NM_001034077
Classification
- H4 histones
VEGA ID

OTTHUMG00000188201

Identity

HGNC:14988
Gene

POFUT1
Long gene name

protein O-fucosyltransferase 1
Synonyms
- O-FUT
- O-Fuc-T
- KIAA0180
- FUT12
Synonyms name
- peptide-O-fucosyltransferase
- GDP-fucose protein O-fucosyltransferase 1
GenBank acession
- AF375884
Locus

20q11.21
Discovery year

2001-10-29
Entrez gene record

23509
Pubmed identfication
- 9023546
- 9525914
RefSeq identity
- NM_015352
Classification
- MicroRNA protein coding host genes
- Fucosyltransferases
VEGA ID

OTTHUMG00000133268

Identity

HGNC:4389
Gene

GNAO1
Long gene name

G protein subunit alpha o1
Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms
- G-ALPHA-o
Locus

16q13
Discovery year

1988-04-24
Entrez gene record

2775
Pubmed identfication
- 1899283
- 11395521
RefSeq identity
- NM_020988
Classification
- G protein subunits alpha, group i
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000133241

Identity

HGNC:20505
Gene

H3C15
Long gene name

H3 clustered histone 15
Synonyms gene
- HIST2H3A
Synonyms gene name
- histone 2, H3a
- histone cluster 2, H3a
- histone cluster 2 H3 family member a
Synonyms
- H3/n
- H3/o
GenBank acession
- AF531305
Locus

1q21.2
Discovery year

2003-02-19
Entrez gene record

333932
Pubmed identfication
- 12408966
- 15527963
Classification
- H3 histones
VEGA ID

OTTHUMG00000012094

Identity

HGNC:3557
Gene

FABP3
Long gene name

fatty acid binding protein 3
Synonyms gene
- MDGI
- FABP11
Synonyms gene name
- fatty acid binding protein 11
- fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
- fatty acid binding protein 3, muscle and heart
Synonyms
- H-FABP
- O-FABP
Synonyms name
- mammary-derived growth inhibitor
GenBank acession
- U57623
Locus

1p35.2
Discovery year

1991-08-06
Entrez gene record

2170
Pubmed identfication
- 8661024
RefSeq identity
- NM_004102
Classification
- Fatty acid binding protein family
VEGA ID

OTTHUMG00000003797

Identity

HGNC:20517
Gene

H2BC19P
Long gene name

H2B clustered histone 19, pseudogene
Synonyms gene
- H2BFO
- HIST2H2BD
Synonyms gene name
- histone 2, H2bd
- H2B histone family, member O
- histone cluster 2, H2bd (pseudogene)
- histone cluster 2 H2B family member d (pseudogene)
Synonyms
- H2B/s
- H2B/o
GenBank acession
- AY131978
Locus

1q21.2
Discovery year

2003-02-20
Entrez gene record

337874
Pubmed identfication
- 12408966
- 15527963
RefSeq identity
- NG_001226
Classification
- H2B histones
VEGA ID

OTTHUMG00000035827