1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

• Catalog number
  I882200
• Price
  Please ask
• Size
  10 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  In Stock
• Cas number
  103745-39-7
• Chemical s molecular weight
  364.28
• Chemical s main applications
  A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
• Chemical s category
  Protein Kinase Inhibitors and Activators
• Other name
  HA1077, Fasudil
• Chemical s formula
  C14H19Cl2N3O2S
• Physical properties
  White to Off-White Solid
• Melting temperature
  >238ºC (dec.)
• Boiling temperature
  No Data Available
• Chemical s soluble in
  Methanol (Slightly), Water (Slightly)
• Stability conditions
  No Data Available
• Storage
  -20°C Freezer
• Chemical s specifications

• Gene target
  5-Isoquinolinesulfonyl   1H-hexahydro-1   4-diazepine   Dihydrochloride  
• Gene symbol
  VSIR
• Short name
  1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1 4-diazepine, Dihydrochloride
• Alternative name
  1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Similar products