VU0467154, M4 Receptor Agonist

• Catalog number
  SIH-184-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  1451993-15-9
• Description
  M4 Receptor Agonist
• Molecular weight
  444,45 g/mol
• Primary research fields
  Neuroscience| Neurotransmitter Receptors, NMDA Receptors, Neurodegeneration
• Other name
  5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C17H15F3N4O3S2
• Origin
  Synthetic
• Purity pourcentage
  95.11%
• Soluble in
  Soluble in DMSO
• Physical appearance
  Tan Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Blue Ice or 4ºC
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  PMC4324418
• Scientific context
  Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
• Bibliography
  1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942.
• Release date
  2-Sep-2015
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol. Chemical structure of VU0467154, a M4 Receptor Agonist (SIH-184). CAS # 1451993-15-9. Molecular Formula: C17H15F3N4O3S2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  VU0467154   Receptor   Agonist  
• Short name
  VU0467154, M4 Receptor Agonist
• Alternative name
  VU0467154, M4 Receptor Agonist

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