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Stock availabilitIn Stock
In Stock
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CAS number
76896-80-5
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Description
Acyl-CoA synthetase inhibitor
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Molecular weight
207,27 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C11H17N3O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO (25 mg/ml) or methanol (5 mg/ml)
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Physical appearance
Oil dissolved in DMSO (1mg/ml)
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
9576787
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Scientific context
Triacsin C is a potent inhibitor of long fatty acyl CoA synthetase. It blocks beta-cell apoptosis. It also blocks the de novo synthesis of triglyercides, diglycerides and cholesterol esters, interfering with lipid metabolism (1). It is also a potent vasodilator.
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Bibliography
1. Igal R.A., Wang P., Coleman R.A. (1997) Biochem J. 324(Pt2): 529-534.
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Release date
16-May-2011
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PubMed number
26016511
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Tested applications
In vitro inhibition
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Tested reactivity
Human
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Representative figure legend
Chemical structure of Triacsin C (SIH-203), a Fatty acyl-CoA synthase inhibitor. CAS #: 76896-80-5. Molecular Formula: C11H17N3O . Molecular Weight: 207.27 g/mol. Chemical structure of Triacsin C, a Fatty acyl-CoA synthase inhibitor (SIH-203). CAS # 76896-80-5. Molecular Formula: C11H17N3O .
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
