TKD Peptide (Hsp70 Peptide), Hsp70 Peptide

• Catalog number
  SIH-118A
• Price
  Please ask
• Size
  1 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  No Available. See included datasheet
• Description
  Hsp70 Peptide
• Molecular weight
  1363 g/mol
• Primary research fields
  Cancer, Heat Shock
• Other name
  none
• Product category
  Small Molecules
• Product type
  Activator
• Chemical formula
  TKDNNLLGRFELSG
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  In aqueous solution
• Physical appearance
  Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  Refer to PubChem
• Scientific context
  Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (1). The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (2). When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the Cterminal half (3). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (4). Heat shock protein 70 has also been found to have a high degree of plasma membrane localization in tumour cell lines. This is correlated with increased sensitivity to lysis mediated by natural killer (NK) cells. The TKD peptide is a partial hsp70 sequence (TKDNNLLGRFELSG- aa. 450-463) and has identical effects on NK cells as full-length Hsp70 protein, being able to stimulate natural killer cells activity at equivalent concentrations to full-length Hsp70 protein (5). Incubation of peripheral blood lymphocyte cells with TKD plus low-dose interleukin 2 (IL-2) enhances the cytolytic activity of NK cells against Hsp70 membrane-positive tumors, in vitro and in vivo (6). Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at more.
• Bibliography
  1. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J.Mol. Evol.38(1): 1-17. 2. Rothman J. (1989), Cell 59: 591 -601. 3. DeLuca-Flaherty et al. (1990) Cell 62: 875-887. 4. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA 89:7290-7294. 5. Multhoff G., et al. (2001) Cell Stress Chaperones 6 (4): 337-344. 6. Krause, S. W. et al. (2004) Clin. Cancer Res. 10(11): 3699-3707.
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
  No representative figure available at this time.
• Representative figure legend
  No representative figure available at this time.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.001
• Other related products
• Additional description
  Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

• Gene target
  TKD   Peptide   Hsp70   Peptide   Hsp70   Peptide  
• Short name
  TKD Peptide (Hsp70 Peptide), Hsp70 Peptide
• Technique
  peptide, peptides
• Alternative name
  TKD short protein sequence (Hsp70 short protein sequence), Hsp70 short protein sequence
• Alternative technique
  peptides

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