Piperlongumine, Apoptosis Inducer

• Catalog number
  SIH-156-100MG
• Price
  Please ask
• Size
  100 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  20069-09-4
• Description
  Apoptosis Inducer
• Molecular weight
  317,3 g/mol
• Primary research fields
  Cancer, Oxidative Stress
• Other name
  1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C17H19NO5
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in 25 mg/ml DMSO
• Physical appearance
  Cream Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
• PubChem number
  637858
• Scientific context
  Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).
• Bibliography
  1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231.
• Release date
  26-Aug-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol. Chemical structure of Piperlongumine, a Apoptosis inducer in oxidative stressed cells (SIH-156). CAS # 20069-09-4. Molecular Formula: C17H19NO5.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.1
• Other related products
• Additional description
  This 1 is suited for programmed cell-death studies.

• Gene target
  Piperlongumine   Inducer  
• Short name
  Piperlongumine, Apoptosis Inducer
• Technique
  apoptosis, apoptosis pathway
• Alternative name
  Piperlongumine, programmed cellular destruction Inducer
• Alternative technique
  celldeath

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