Nicardipine HCl, L-type Ca channel blocker

• Catalog number
  SIH-313-250MG
• Price
  Please ask
• Size
  250 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  54527-84-3
• Description
  L-type Ca channel blocker
• Molecular weight
  515,99 g/mol
• Primary research fields
  Neuroscience, Ion Channels, Calcium Channels, Voltage-Gated Calcium Channels
• Other name
  2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C26H29N3O6•HCl
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water.
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) Risk Phrases: R23/24/25- Toxic by inhalation, if swallowed and in contact with skin. Hazard Phrases: H301-H311-H331 Precautionary Phrases: P261-P280-P301 + P310-P311
• PubChem number
  41114
• Scientific context
  Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud’s phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calcium ions into the cardiac muscle and smooth muscle without changing the serum calcium concentrations.
• Bibliography
  1. Huang R.I., et al. (2006) Catheter Cardiovasc Interv. 68(5): 671-676.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Nicardipine HCl (SIH-313), a L-type Ca channel blocker. CAS #: 54527-84-3. Molecular Formula: C26H29N3O6 · HCl. Molecular Weight: 515.99 g/mol. Chemical structure of Nicardipine HCl, a L-type Ca channel blocker (SIH-313). CAS # 54527-84-3. Molecular Formula: C26H29N3O6 · HCl.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.25
• Other related products

• Gene target
  Nicardipine   HCl   channel   blocker  
• Short name
  Nicardipine HCl, L- Ca channel blocker
• Alternative name
  Nicardipine HCl, L-classification Ca channel blocker

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