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Stock availabilitIn Stock
In Stock
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CAS number
1953-04-4
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Description
Acetylcholinesterase inhibitor
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Molecular weight
368,3 g/mol
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Primary research fields
Neuroscience, Neurodegeneration, Alzheimer’s Disease, Cancer, Apoptosis
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Other name
Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C17H22BrNO3
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Origin
Synthetic
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Purity pourcentage
>97% (HPLC); NMR (Conforms)
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Soluble in
Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
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Physical appearance
White powder
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Storage recommendations
-20ºC
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Shipping recommendations
Blue Ice or 4ºC
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Safety information
Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion Hazard statement(s): H301 Toxic if swallowed. Precautionary statement(s): P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
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PubChem number
121587
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Scientific context
Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice.
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Release date
30/Aug/2016
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Galanthamine HBr (SIH-530), a Acetylcholinesterase inhibitor. CAS #: 1953-04-4. Molecular Formula: C17H22BrNO3. Molecular Weight: 368.3 g/mol. Chemical structure of Galanthamine HBr, a Acetylcholinesterase inhibitor (SIH-530). CAS # 1953-04-4. Molecular Formula: C17H22BrNO3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.02
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
