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Stock availabilitIn Stock
In Stock
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CAS number
116355-83-0
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Description
Ceramide synthase inhibitor
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Molecular weight
721,83 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
2,2'-{(19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl)bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C34H59NO15
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 10 mM in DMSO
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Physical appearance
Beige Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed R60- May impair fertility R61- May cause harm to the unborn child Hazard Phrases: H351 Precautionary Phrases: P281
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PubChem number
3431
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Scientific context
Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2).
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Bibliography
1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27). 2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Fumonisin B1 (SIH-234), a Blocks sphingolipid biosynthesis. CAS #: 116355-83-0. Molecular Formula: C34H59NO15. Molecular Weight: 721.83 g/mol. Chemical structure of Fumonisin B1, a Blocks sphingolipid biosynthesis (SIH-234). CAS # 116355-83-0. Molecular Formula: C34H59NO15.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
