CPD5, MPS1/TTK Inhibitor

• Catalog number
  SIH-183-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  No Available. See included datasheet
• Description
  MPS1/TTK Inhibitor
• Molecular weight
  580,74 g/mol
• Primary research fields
  Cancer, Cell Signaling
• Other name
  N-(2,6-diethylphenyl)-8-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C33H40N8O2
• Origin
  Synthetic
• Purity pourcentage
  99%
• Soluble in
  Soluble in CDCI3
• Physical appearance
  Yellow Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Blue Ice or 4ºC
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  Refer to PubChem
• Scientific context
  This is a protein kinase inhibitor with activity against MPS1/TTK. It has an IC50 of 0.10 µM in cellular proliferation inhibition assay using A2780 cells.
• Bibliography
  1. Caldarelli, M., et al. (2011) Bioorganic & Medicinal Chemistry Letters 21.15: 4507-4511.
• Release date
  2-Sep-2015
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of CPD5 (SIH-183), a MPS1/TTK Inhibitor. CAS #: . Molecular Formula: C33H40N8O2. Molecular Weight: 580.74 g/mol. Chemical structure of CPD5, a MPS1/TTK Inhibitor (SIH-183). CAS # . Molecular Formula: C33H40N8O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  CPD5   MPS1/TTK   Inhibitor  
• Gene symbol
  TTK, IDUA, RPS27
• Short name
  CPD5, MPS1/TTK Inhibitor
• Alternative name
  CPD5, MPS1/TTK suppressor

Gene info

• Identity
  HGNC:12401
• Gene
  TTK
• Long gene name
  TTK protein kinase
• Synonyms
  • MPS1
  • MPS1L1
  • CT96
  • MPH1
• Synonyms name
  • cancer/testis antigen 96
  • monopolar spindle 1 kinase
• Locus
  6q14.1
• Discovery year
  1995-07-11
• Entrez gene record
  7272
• Pubmed identfication
  • 1639825
• VEGA ID
  OTTHUMG00000015088

Gene info

• Identity
  HGNC:5391
• Gene
  IDUA
• Long gene name
  alpha-L-iduronidase
• Synonyms gene name
  • iduronidase, alpha-L-
• Synonyms
  • MPS1
  • MPSI
• Synonyms name
  • mucopolysaccharidosis type I
• GenBank acession
  • M74715
• Locus
  4p16.3
• Discovery year
  2001-06-22
• Entrez gene record
  3425
• Pubmed identfication
  • 1832239
• RefSeq identity
  • NM_000203
• Classification
  • Glycoside hydrolases
• VEGA ID
  OTTHUMG00000088901
• Locus Specific Databases
  • LRG_1277

Gene info

• Identity
  HGNC:10416
• Gene
  RPS27
• Long gene name
  ribosomal protein S27
• Synonyms gene name
  • ribosomal protein S27 (metallopanstimulin 1)
• Synonyms
  • MPS-1
  • MPS1
  • S27
• Synonyms name
  • metallopanstimulin 1
• GenBank acession
  • U57847
• Locus
  1q21.3
• Discovery year
  1998-06-05
• Entrez gene record
  6232
• Pubmed identfication
  • 8908372
  • 8407955
• RefSeq identity
  • NM_001030
• Classification
  • S ribosomal proteins
• VEGA ID
  OTTHUMG00000036591
• Locus Specific Databases
  • LRG_1158

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