17-DMAG, Hsp90 inhibitor

• Catalog number
  SIH-114A
• Price
  Please ask
• Size
  1 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  30562-34-6
• Description
  Hsp90 inhibitor
• Molecular weight
  616,8 g/mol
• Primary research fields
  Cancer, Heat Shock
• Other name
  none
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C32H48N4O8
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
• Physical appearance
  Purple Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  9852573
• Scientific context
  17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
• Bibliography
  1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077. 2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381. 3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of 17-DMAG (SIH-114), a Hsp90 inhibitor. CAS #: 30562-34-6. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol. Chemical structure of 17-DMAG, a Hsp90 inhibitor (SIH-114). CAS # 30562-34-6. Molecular Formula: C32H48N4O8.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.001
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  17-DMAG   Hsp90   inhibitor  
• Gene symbol
  PIRC95, PIRC91, PIRC90, PIRC93, PIRC92, SNORD115-17, IGHV3OR16-17, SNORD116-17
• Short name
  17-DMAG, Hsp90 inhibitor
• Alternative name
  17-DMAG, Hsp90 suppressor

Gene info

• Identity
  HGNC:37599
• Gene
  PIRC95
• Long gene name
  piwi-interacting RNA cluster 95
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313935
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37595
• Gene
  PIRC91
• Long gene name
  piwi-interacting RNA cluster 91
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313900
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37594
• Gene
  PIRC90
• Long gene name
  piwi-interacting RNA cluster 90
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313798
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37597
• Gene
  PIRC93
• Long gene name
  piwi-interacting RNA cluster 93
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313934
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37596
• Gene
  PIRC92
• Long gene name
  piwi-interacting RNA cluster 92
• Locus
  17
• Discovery year
  2009-11-05
• Entrez gene record
  100313920
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33036
• Gene
  SNORD115-17
• Long gene name
  small nucleolar RNA, C/D box 115-17
• Synonyms
  • HBII-52-17
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033455
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003309.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:55105
• Gene
  IGHV3OR16-17
• Long gene name
  immunoglobulin heavy variable 3/OR16-17 (non-functional)
• Synonyms
  • IGHV3/OR16-17
• Locus
  16p11.2
• Discovery year
  2020-06-26
• Entrez gene record
  390714
• Classification
  • Immunoglobulin heavy (IGH) orphons

Gene info

• Identity
  HGNC:33083
• Gene
  SNORD116-17
• Long gene name
  small nucleolar RNA, C/D box 116-17
• Synonyms
  • HBII-85-17
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033429
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003332
• Classification
  • Small nucleolar RNAs, C/D box

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