sCD27 Ligand Recombinant Protein

• Catalog number
  40-568
• Price
  Please ask
• Size
  0.01 mg, 0.05 mg

• About recombinant protein
  CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the immune response by promoting T-cell expansion and differentiation, as well as NK enhancement. CD27 signaling can act as a co-stimulatory effector to sustain the survival of CD8+ T cells, primarily by inducing increased expression of the IL-2 gene. Full length human CD27L is a 193 amino acid protein, consisting of a 17 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 155 amino acid extracellular domain. Human soluble CD27L corresponds to the 155 amino acid extracellular domain of the full length CD27L protein. ProSci’s recombinant human sCD27L contains the extracellular domain plus an N-terminal His-Tag.
• Other name of the recombinant
  CD27L, CD27LG, TNFSF7, CD27L, CD70 antigen, CD27 ligand, CD27-L
• Recombinant in
  CHO cells
• SEQUENCE
  HHHHHHHHPS PGGSGGQRFA QAQQQLPLES LGWDVAELQL NHTGPQQDPR LYWQGGPALG RSFLHGPELD KGQLRIHRDG IYMVHIQVTL AICSSTTASR HHPTTLAVGI CSPASRSISL LRLSFHQGCT IASQRLTPLA RGDTLCTNLT GTLLPSRNTD ETFFGVQWVR P
• Activity
  Biological activity was determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/mL. Note: Results may vary with PBMC donors. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• Keep at
  The lyophilized sCD27 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted sCD27 Ligand stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing sCD27 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  4507605
• Accession nr
  NP_001243.1
• Pureity
  Greater than 95% by SDS-PAGE gel and HPLC analyses.
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  970
• Gene name
  CD70 molecule
• Source
  Homo sapiens
• Uniprot
  P32970
• Pictures of recombinant
• Rec pdf
• Description
  FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  sCD27   Ligand   Protein  
• Gene symbol
  CD70
• Short name
  sCD27 Ligand Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  sCD27 Ligand Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11937
• Gene
  CD70
• Long gene name
  CD70 molecule
• Synonyms gene
  • CD27LG
  • TNFSF7
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 7
• Synonyms
  • CD27L
• GenBank acession
  • L08096
• Locus
  19p13.3
• Discovery year
  1993-11-08
• Entrez gene record
  970
• Pubmed identfication
  • 8387892
  • 8120384
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000181834

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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