anti-NOX2 Antibody

• Catalog number
  7923
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX2, also known as cytochrome b beta (CYBB) is one of two proteins that make up Cytochrome b-245, thought to be a primary component of the microbicidal oxidase system of phagocytes. NOX2 deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD) (2). Activation of the NOX2 enzyme complex in microglia is thought to be neurotoxic and may play a role in Alzheimer’s and Parkinson’s disease (3).
• Gene names
  NOX2 Antibody: CGD, NOX2, AMCBX2, GP91-1, GP91PHOX, p91-PHOX, GP91-PHOX, Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b558 subunit beta
• Antibodie s label
  unlabelled serum
• Purity
  NOX2 antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  NOX2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NOX2 is predicted to not cross-react with other NOX proteins.
• Antigen
  Rabbit polyclonal NOX2 antibody was made against a 15 amino acid peptide near the amino terminus of human NOX2.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  NOX2 antibody can be used for detection of NOX2 by Western blot at 1 - 2 ug/ml. Antibody can also be used for Immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  NOX2 antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  NOX2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  6996021
• Ncbi nr
  NP_000388
• KDa
  Predicted: 59, 63 kDa Observed: 58 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  1536
• GENE symbol
  CYBB
• Antigene name
  cytochrome b-245, beta polypeptide
• Source
  homo sapiens
• Protein nr
  P04839
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NOX2  
• Gene symbol
  CYBB
• Short name
  anti-NOX2 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toNOX2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2578
• Gene
  CYBB
• Long gene name
  cytochrome b-245 beta chain
• Synonyms gene
  • CGD
• Synonyms gene name
  • chronic granulomatous disease
  • cytochrome b-245, beta polypeptide
• Synonyms
  • GP91-PHOX
  • NOX2
• Synonyms name
  • NADPH oxidase 2
• GenBank acession
  • X04011
• Locus
  Xp21.1-p11.4
• Discovery year
  1986-01-01
• Entrez gene record
  1536
• VEGA ID
  OTTHUMG00000033175
• Locus Specific Databases
  • CYBBbase: Mutation registry for X-linked chronic granulomatous disease (previously known as X-CDGbase)
  • LRG_53

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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