anti-DNase II Antibody

• Catalog number
  2059
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  DNase II Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation. DNase II is ubiquitously expressed in human tissues.
• Gene names
  DNase II Antibody: DNL, DNL2, DNASE2A, Deoxyribonuclease-2-alpha, Acid DNase, DNase II alpha
• Antibodie s label
  unlabelled serum
• Purity
  DNase II Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  DNase II antibody was made against a 14 amino acid peptide near the carboxy terminus of human DNase II.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  DNase II antibody can be used for detection of DNase II expression by Western blot at 0.5 ug/mL. An approximate 40 kDa band can be detected, which represents the pro-enzyme of DNase II. Antibody can also be used for immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  DNase II Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  DNase II antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  2921838
• Ncbi nr
  AF047016
• KDa
  Aprox: 40 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  1777
• GENE symbol
  DNASE2
• Antigene name
  deoxyribonuclease II, lysosomal
• Source
  Homo sapiens
• Protein nr
  O00115
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DNase  
• Gene symbol
  SET
• Short name
  anti-DNase II Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toDNase II (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10760
• Gene
  SET
• Long gene name
  SET nuclear proto-oncogene
• Synonyms gene name
  • SET translocation (myeloid leukemia-associated)
• Synonyms
  • PHAPII
  • 2PP2A
  • IPP2A2
  • TAF-IBETA
  • IGAAD
  • TAF-I
• Synonyms name
  • protein phosphatase type 2A inhibitor
  • Template-Activating Factor-I
  • chromatin remodelling factor
  • HLA-DR-associated protein II
  • inhibitor of granzyme A-activated DNase
• GenBank acession
  • M93651
• Locus
  9q34.11
• Discovery year
  1998-04-20
• Entrez gene record
  6418
• Pubmed identfication
  • 1630450
  • 8626647
• RefSeq identity
  • NM_001122821
• Classification
  • INHAT complex
  • SET complex
• VEGA ID
  OTTHUMG00000020755

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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