anti-Caspase-10 Antibody

• Catalog number
  1128
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Caspase-10 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.
• Gene names
  Caspase-10 Antibody: MCH4, Caspase-10, Apoptotic protease Mch-4, CASP-10
• Antibodie s label
  unlabelled serum
• Purity
  Caspase-10 Antibody is Antibody is DEAE purified.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  Antibody only recognizes FLICE2 form of caspase-10.
• Antigen
  Caspase-10 antibody was made against a 17 amino acid peptide near the carboxy terminus of human Caspase-10.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  Caspase-10 antibody can be used for detection of caspase-10 by Western blot 1 ug/mL. A 59 kDa band can be detected.
• Suspention pH azide
  Caspase-10 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Caspase-10 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  4731237
• Ncbi nr
  AAD28402
• Vial with antibody
  in solution
• NCBI GENE nr
  843
• GENE symbol
  CASP10
• Antigene name
  caspase 10, apoptosis-related cysteine peptidase
• Source
  Homo sapiens
• Protein nr
  Q92851
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Caspase-10  
• Gene symbol
  CARD10, CASP10, RFFL
• Short name
  anti-Caspase-10 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCasp-10 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16422
• Gene
  CARD10
• Long gene name
  caspase recruitment domain family member 10
• Synonyms gene name
  • caspase recruitment domain family, member 10
• Synonyms
  • CARMA3
  • BIMP1
• GenBank acession
  • AF086324
• Locus
  22q13.1
• Discovery year
  2002-09-19
• Entrez gene record
  29775
• Pubmed identfication
  • 11259443
  • 11356195
• RefSeq identity
  • NM_014550
• Classification
  • Membrane associated guanylate kinases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000150592

Gene info

• Identity
  HGNC:1500
• Gene
  CASP10
• Long gene name
  caspase 10
• Synonyms gene name
  • caspase 10, apoptosis-related cysteine protease
  • caspase 10, apoptosis-related cysteine peptidase
• Synonyms
  • MCH4
  • FLICE-2
• Synonyms name
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
• GenBank acession
  • U60519
• Locus
  2q33.1
• Discovery year
  1997-04-21
• Entrez gene record
  843
• Pubmed identfication
  • 8755496
• RefSeq identity
  • NM_032977
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
• VEGA ID
  OTTHUMG00000132818
• Locus Specific Databases
  • CASP10base: Mutation registry for Autoimmune lymphoproliferative syndrome, type II (ALPS2)
  • LRG_33

Gene info

• Identity
  HGNC:24821
• Gene
  RFFL
• Long gene name
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
• Synonyms gene name
  • ring finger and FYVE-like domain containing
• Synonyms
  • rififylin
  • fring
  • RNF189
  • RNF34L
  • CARP2
  • CARP-2
• Synonyms name
  • caspase 8 and 10 associated RING protein-2
• GenBank acession
  • AF434816
• Locus
  17q12
• Discovery year
  2005-08-16
• Entrez gene record
  117584
• Pubmed identfication
  • 15229288
• RefSeq identity
  • NM_057178
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000132933

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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