ProFoldin
ProFoldin is a biotechnology company based in Hudson, Massachusetts, USA, specializing in protein folding, drug discovery, drug delivery, and biochemical assays. Established in 2005, ProFoldin offers a range of innovative tools and services aimed at advancing life sciences and pharmaceutical research.
Core Technologies and Products
1. Protein Folding and Membrane Protein Sciences
- Protein Folding Columns: ProFoldin's protein folding columns are designed to produce active proteins from denatured inclusion bodies. These columns facilitate the refolding process, enabling the recovery of functional proteins for further study and application.
- Membrane Protein Folding Kits: The Spin-column Membrane Protein Folding Screen Kit is specifically designed for folding membrane proteins from urea-solubilized inclusion bodies or other protein aggregates. The kit includes 20 protein folding spin columns and reagents representing various folding conditions.
- Preparative Folding Kits: After identifying optimal folding conditions, researchers can use preparative kits to fold larger quantities (5–10 mg) of proteins. These kits include multiple columns and necessary reagents for large-scale folding experiments.
2. Drug Discovery and Enzyme Assays
- High-Throughput Assays: ProFoldin provides enzyme assay kits for drug discovery, enabling the screening of potential drug candidates. These assays are designed for high-throughput applications, facilitating the rapid evaluation of compound libraries.
- Topoisomerase Assays: Topoisomerases are enzymes that play essential roles in DNA replication and are important targets for cancer chemotherapy treatments and antibiotics. ProFoldin offers a selection of high-throughput assays for topoisomerase functions, including DNA relaxation, DNA supercoiling, DNA decatenation, and ATP hydrolysis. These assays are available in 96-well or 384-well plate formats, suitable for drug testing and HTS applications.
3. Drug Delivery and Liposome Technologies
- Liposome and Nanodisc Products: Utilizing nanotechnology, ProFoldin produces various liposomes and nanodiscs suitable for research and industrial applications. These products include ready-to-load liposomes for drug delivery, drug-loaded liposomes, and liposomes loaded with dyes, ions, and biomolecules. Additionally, ProFoldin offers nanodiscs for membrane protein reconstitution, providing a platform for studying membrane proteins in a controlled environment.
4. Biochemical Assays and Concentration Measurement
- Concentration Assay Kits: ProFoldin offers high-throughput assays for measuring the concentration of various molecules and ions, including biomolecules, lipids, detergents, and metal ions. These assays are essential for characterizing biochemical reactions and ensuring the accuracy of experimental conditions.
1 mM Ciprofloxacin
SKU: CIP10|Size: 100 µL
1 mM Novobiocin
SKU: NOV10|Size: 100 µL
10 mM AMP-PCP, an ATPase inhibitor
SKU: AMP-PCP10|Size: 100 µL
10 mM Doxorubicin hydrochloride
SKU: DOX10|Size: 100 µL
10 mg/ml Penicillin G, sodium
SKU: PEN10|Size: 100 µL
10 nm DOPC Nanodisc
SKU: ND-OCGS-10|Size: 90 mg
10 x Assay Buffer for Human DNA Topoisomerase I Assays
SKU: HT1BUF-10|Size: 10 mL
10 x Assay Buffer for Human DNA polymerases A, B, G
SKU: HDPA-BUF10|Size: 10 mL
10x H19 dilution buffer
SKU: H19BUF-10|Size: 100 mL
30 nm DOPC Nanodisc
SKU: ND-OCGS-30|Size: 90 mg
96-Well E. coli Topo I DNA Decatenation Assay Kit Plus (enzyme included)
SKU: T1DD-96KE|Size: 96 Assays
96-Well E. coli Topo IV DNA Decatenation Assay Kit Plus (enzyme included)
SKU: EDD96KE|Size: 96 Assays
96-Well E. coli gyrase DNA Decatenation Assay Kit Plus (enzyme included)
SKU: T2DD-96KE|Size: 96 Assays
96-Well Human Topo II DNA Decatenation Assay Kit Plus (enzyme included)
SKU: HDD96KE|Size: 96 Assays
96-Well P. aeruginosa Topo IV DNA Decatenation Assay Kit Plus (enzyme included)
SKU: PDD96KE|Size: 96 Assays
96-Well Protein Folding Plate
SKU: PFS096|Size: 1 Kit
96-Well S. aureus Topo IV DNA Decatenation Assay Kit Plus (enzyme included)
SKU: SDD96KE|Size: 96 Assays
96-Well S. aureus gyrase DNA Decatenation Assay Kit Plus (enzyme included)
SKU: T2DD-96KS|Size: 96 Assays
96-Well S. pneumoniae Topo IV DNA Decatenation Assay Kit Plus (enzyme included)
SKU: NDD96KE|Size: 96 Assays
96-Well Topoisomerase DNA Decatenation Assay Kit (enzyme not included)
SKU: TDD96K|Size: 96 Assays
96-well Anionic Protein-binding Plates (black)
SKU: APP96B|Size: 4 Plates
96-well Anionic Protein-binding Plates (transparent)
SKU: APP96T|Size: 4 Plates
96-well Cationic Protein-binding Plates (black)
SKU: CPP96B|Size: 4 Plates
96-well Cationic Protein-binding Plates (transparent)
SKU: CPP96T|Size: 4 Plates
96-well DNA–binding Plates (Transparent)
SKU: NBP96T|Size: 4 Plates
96-well DNA–binding plates (black)
SKU: NBP96B|Size: 4 Plates
96-well E. coli Gyrase DNA Cleavage Assay Kit Plus (enzyme included)
SKU: T2C96KE|Size: 96 Assays
96-well E. coli Topo IV DNA Cleavage Assay Kit Plus
SKU: T4C96KE|Size: 96 Assays
96-well S. aureus Topo IV DNA Cleavage Assay Kit Plus (enzyme included)
SKU: T4C96KS|Size: 96 Assays
96-well Super High Binding ELISA Plates – Black
SKU: ELISA96B|Size: 4 Plates
96-well Super High Binding ELISA Plates – Transparent
SKU: ELISA96T|Size: 4 Plates
96-well Topoisomerase DNA Cleavage Assay Kit (enzyme not included)
SKU: TDC96K|Size: 96 Assays
AMV Reverse Transcriptase Assay Kit (enzyme not included)
SKU: AMV100K-|Size: 100 assays
AMV Reverse Transcriptase Assay Kit Plus (enzyme included)
SKU: AMV100KE|Size: 100 Assays
Amino Acid Assay Kit
SKU: AAK1000|Size: 1000 Assays
Bacterial RNA Polymerase Pyrophosphate Assay Kit (enzyme not included)
SKU: RPAP100K|Size: 100 Assays
Bacteriophage T4 DNA Ligase Assay Kit
SKU: T4L100K|Size: 100 Assays
Bacteriophage T4 DNA Ligase Assay Kit Plus
SKU: T4L100KE|Size: 100 Assays
Bacteriophage T7 DNA Ligase Assay Kit
SKU: T7L100K|Size: 100 Assays
Bacteriophage T7 DNA Ligase Assay Kit Plus
SKU: T7L100KE|Size: 100 Assays
Beta Lactamase Assay Kit
SKU: LAC100K|Size: 100 Assays
Beta Nonyl Glucoside (ß-NG) Assay Kit
SKU: NG100K|Size: 100 Assays
Beta Octyl Glucoside (ß-OG) Assay Kit
SKU: OG100K|Size: 100 Assays
Cell Detection Dye
SKU: CDD200|Size: 0.1 mL
Cholesterol: DSPG-PEG2000 Liposome
SKU: PHPC100AS1|Size: 10 mL
Citrate Assay kit
SKU: CIT100|Size: 100 assays
Coenzyme A Assay Kit
SKU: CAK1000|Size: 1000 Assays
Colorimetric DTT Assay kit
SKU: DTT100C|Size: 100 Assays
Colorimetric S-Adenosyl Methionine (SAM) Assay Kit
SKU: SAM100|Size: 100 Units
DDC Spin-columns for DNA decatenation assays (enzyme not included)
SKU: DDC100|Size: 100 assays
DNA Topoisomerase DNA decatenation Assay Kit (enzyme not included)
SKU: DDC020K|Size: 20 Assays
DNA Topoisomerase I Assay Kit (enzyme not included)
SKU: DRA020K|Size: 20 Assays
DNA Topoisomerase I assay reagent Set for HTS (enzyme not included)
SKU: DRA1000|Size: 1000 assays
DNA Topoisomerase II (Gyrase) Assay Kit (enzyme not included)
SKU: DSA020K|Size: 20 Assays
DNA polymerase Assay Kit (enzyme not included)
SKU: DPA100K|Size: 100 Assays
DNA-Binding Fluorescence Interference Assay Kit
SKU: DBF100K|Size: 100 Assays
DPPC Liposomal Ciprofloxacin- 2 mg
SKU: DPPC002CP|Size: 2 mg
DPPC Liposome for DNA and RNA Nanoparticles
SKU: DCDA20|Size: 2 mL
DPPC: Cholesterol Liposome
SKU: DPC100AT1|Size: 10 mL
Detergent Critical Micelle Concentration (CMC) Assay Kit
SKU: CMC1000|Size: 1000 Assays
Detergent assay kit
SKU: DAK1000|Size: 1000 Assays
Dilution Membrane Protein Folding Screen Kit
SKU: MPS01-20|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #1)
SKU: MPP01|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #10)
SKU: MPP10|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #11)
SKU: MPP11|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #12)
SKU: MPP12|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #13)
SKU: MPP13|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #14)
SKU: MPP14|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #15)
SKU: MPP15|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #16)
SKU: MPP16|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #17)
SKU: MPP17|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #18)
SKU: MPP18|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #19)
SKU: MPP19|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #2)
SKU: MPP02|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #20)
SKU: MPP20|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #3)
SKU: MPP03|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #4)
SKU: MPP04|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #5)
SKU: MPP05|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #6)
SKU: MPP06|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #7)
SKU: MPP07|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #8)
SKU: MPP08|Size: kit
Dilution Preparative Membrane Protein Folding Kit (Condition #9)
SKU: MPP09|Size: kit
E. coli Beta Lactamase Assay Kit Plus
SKU: LAC100KE|Size: 100 Assays
E. coli Biotin Protein Ligase Assay Kit Plus-100
SKU: BPL100KE|Size: 100 Assays
E. coli Biotin Protein Ligase Assay Kit Plus-500
SKU: BPL500KE|Size: 500 Assays
E. coli BirA - for 100 assays
SKU: BIRA-100KEC|Size: 100 Assays
E. coli D-Ala-D-Ala ligase - for 100 assays
SKU: DDL-100EC|Size: 100 Assays
E. coli D-Alanine: D-Alanine Ligase Assay Kit Plus-100
SKU: DDA100KE|Size: 100 Assays
E. coli D-Alanine: D-Alanine Ligase Assay Kit Plus-500
SKU: DDA500KE|Size: 500 Assays
E. coli DNA Helicase ATPase assay Kit Plus-100
SKU: DNAB100KE|Size: 100 Assays
E. coli DNA Helicase ATPase assay Kit Plus-500
SKU: DNAB500KE|Size: 500 Assays
E. coli DNA Primase Assay Kit (enzyme not included)
SKU: EGA100K|Size: 100 Assays
E. coli DNA Primase Assay Kit Plus (E. coli primase-helicase included)
SKU: EGA100KE|Size: 100 Assays
E. coli DNA Topoisomerase I Assay Kit Plus (E. coli Topo I included)
SKU: DRA020KE|Size: 20 Assays
E. coli DNA Topoisomerase I Assay Kit Plus-100 (enzyme included)
SKU: DRA100KE|Size: 100 Assays
E. coli DNA Topoisomerase II (Gyrase) Assay Kit Plus (E. coli gyrase included)
SKU: DSA020KE|Size: 20 Assays
E. coli DNA Topoisomerase II (Gyrase) Assay Kit Plus-100 (enzyme included)
SKU: DSA100KE|Size: 100 Assays
E. coli DNA Topoisomerase IV Assay Kit Plus (E. coli Topo IV included)
SKU: DDC020KE|Size: 20 Assays
E. coli DNA Topoisomerase IV Assay Kit Plus-100 (enzyme included)
SKU: DDC100KE|Size: 100 Assays
E. coli DNA gyrase - for 100 assays
SKU: TOP2-100EC|Size: 100 Assays
DNA topoisomerase assay kits
H. influenzae DNA Primase Assay Kit Plus (enzyme included)
SKU: HGA100KE|Size: 100 Assays
Human topoisomerase I DNA relaxation assay kit (enzyme not included)
SKU: HRA020K|Size: 20 Assays
Human Topoisomerase I DNA Relaxation Assay Kit -100
SKU: HRA100K|Size: 100 Assays
Human Topoisomerase I DNA Relaxation Assay Kit Plus -100
SKU: HRA100KE|Size: 100 Assays