ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) (ICOSL/3260), CF740 conjugate, 0.1mg/mL

CAT: 0037-BNC743260-500Size: 1x 500 µLDry Ice: NoHazardous: No
CAT#:0037-BNC743260-500Size:1x 500 µL
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Description
This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2. 4, 3. 0, and 7. 0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1. 1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
B7 homolog 2 (B7H2) ; B7 like protein Gl50; B7 related protein 1 (B7RP1) ; CD275; CD275 antigen; GL50; ICOS LG; ICOS ligand (ICOSL) ; Inducible T cell co stimulator ligand; LICOS; Transmembrane protein B7 H2 ICOS ligand
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ICOSLG
Gene ID
23308
NCBI Gene ID
14155
UniProt
O75144
Swiss Prot
O75144
Host
Mouse
Species Reactivity
Human
Reactivity
B7RP-1|ICOS Ligand|ICOS-L
Immunogen
Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
Target Antigen
B7RP-1 | ICOS Ligand | ICOS-L
Clonality
Monoclonal
Clone
ICOSL/3260
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Positive Control
HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% rBSA, 0.05% azide
Molecular Weight
36 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2b, kappa
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF740
Product Datasheet
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Product MSDS
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