Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker) (AACT/1452), 0.2mg/mL

CAT: 0037-BNUB1452-500Size: 1x 500 µLDry Ice: NoHazardous: No
CAT#:0037-BNUB1452-500Size:1x 500 µL
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Description
Alpha-1 Antichymotrypsin (AACT) is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of alpha-1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Alpha-1-antichymotrypsin; Serpin A3; SERPINA3; AACT; ACT; Cell growth-inhibiting gene 24/25 protein; Growth inhibiting protein 24; Growth inhibiting protein 25; Serine (or cysteine) proteinase inhibitor clade A member 3
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
SERPINA3
Gene ID
12
NCBI Gene ID
534293; 710488
UniProt
P01011
Swiss Prot
P01011
Host
Mouse
Species Reactivity
Human
Reactivity
Alpha-1 Antichymotrypsin
Immunogen
Recombinant human Antichymotrypsin (AACT) protein fragment (aa49-187) (exact sequence is proprietary)
Target Antigen
Alpha-1 Antichymotrypsin
Clonality
Monoclonal
Clone
AACT/1452
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Field of Research
Cancer
Positive Control
HeLa Cells. Tonsil, Pancreas or Histiocytoma.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
65-76 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Product Datasheet
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Product MSDS
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