Human TOP2A / TOP2 Protein, Tag Free

• Background:

  DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

• Description:

  Human TOP2A, Tag Free (TOA-H5117) is expressed from E. coli cells. It contains AA Ser 1354 - Ser 1473 (Accession # P11388-1) .

• Specifications:

  This protein carries no "tag". The protein has a calculated MW of 13.0 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE) .

• Accession Number:

  P11388-1

• Expression Region:

  Ser 1354 - Ser 1473

• Host:

  E. coli

• Target:

  TOP2A

• Conjugation:

  Unconjugated

• Tag:

  Native

• Source:

  Human

• Stability:

  ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.

• Endotoxin:

  1.0 EU per μg

• Purity:

  90%

• Format:

  Liquid

• Buffer:

  50 mM Tris, 0.5 M KCl, pH8.0

• Additives:

  Glycerol

• Molecular Weight:

  13.0 kDa

• Shipping Conditions:

  Dry ice

• Storage Conditions:

  -70°C

• Package Size:

  100ug*1

• Species:

  Human