VHR VH1-related phosphatase human, recombinant, E. coli

• Description:

  The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases (ERKs). Vaccinia Virus VH1-related Phosphatase (VHR), also known as Dual-Specificity Phosphatase 3 (DUSP3), removes phosphate groups from tyrosine, serine, and threonine residues. It belongs to a family of phosphatases that selectively dephosphorylate MAP kinases. VHR has been shown to act as a phosphatase for several members of the MAP kinase family including ERK1, ERK2, and JNK. It is a target for the ZAP-70 kinase, and phosphorylation of VHR at tyrosine 138 leads to a downregulation of ERK2 activity. Its welldefined biochemistry has made VHR useful in screening assays for compounds that inhibit phosphatases.

• UNSPSC:

  12352202

• UNSPSC Description:

  Proteins

• HS Code:

  35079090

• Accession Number:

  NM_004090

• eClass Number:

  34160400

• eClass Product Group:

  Peptide and Protein

• Purity:

  > 90 % (SDS-PAGE)

• Form:

  Liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA and 1 mM DTT)

• Autoclavability:

  false

• Shipping Conditions:

  Shipped on dry ice.

• Storage Conditions:

  Store at -80 °C. Avoid freeze/thaw cycles.

• Shelf Life:

  12 months

• CAS Number:

  9000-83-3