CD2 (UMCD2), CF740 conjugate, 0.1mg/mL

CAT: 0037-BNC741235-100Size: 1x 100 µLDry Ice: NoHazardous: No
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CAT#:0037-BNC741235-100Size:1x 100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Erythrocyte receptor; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD2
Gene ID
914
NCBI Gene ID
523500
UniProt
P06729
Swiss Prot
P06729
Host
Mouse
Species Reactivity
Human
Reactivity
CD2
Immunogen
Human Thymocytes/Sezary T cells
Target Antigen
CD2
Clonality
Monoclonal
Clone
UMCD2
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow (verified) |Flow, surface (published) |Functional studies (published) |WB (published) |WB (verified)
Field of Research
Immunology
Positive Control
293T or Jurkat cells. Lymph node and tonsil
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% rBSA, 0.05% azide
Molecular Weight
~50 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Cellular Immunol (1993) 150(2): 235-246. (Flow, surface; WB; functional studies)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a, kappa
Species
Mus musculus (mouse), Bos taurus (bovine)
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF740
Product Datasheet
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