CD59 (heavy chain of Protectin) (193-27), 0.2mg/mL

CAT: 0037-BNUB0182-500Size: 1x 500 µLDry Ice: NoHazardous: No
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Description
Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein (Workshop VI; Code N-L036) . CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions. This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.
CAS Number
9007-83-4
Synonyms
20kDa homologous restriction factor (HRF20) ; Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD59
Gene ID
966
NCBI Gene ID
278573; 709466; 710641
UniProt
P13987
Swiss Prot
P13987
Host
Mouse
Species Reactivity
Human
Reactivity
CD59
Immunogen
Stimulated human leukocytes
Target Antigen
CD59
Clonality
Monoclonal
Clone
193-27
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, surface (published) |Functional studies (published) |IHC, FFPE (verified)
Field of Research
Hematology, Immunology
Positive Control
Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Human lymph node and tonsil.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
20 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Blood (2001) 98(9): 2771-2777. (Flow, surface; functional studies)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgM, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Product Datasheet
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36-1951-100Monoclonal Antibody to CD59 / Complement Regulatory Protein / Protectin (Clone : 193-27)
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AMM01592GMonoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: 193-27
A22553-25ML-193 25mg
A22553-10ML-193 10mg
A22553-5ML-193 5mg
A22553-50ML-193 50mg
A22553-100ML-193 100mg
AMM01593GMonoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: 193-27

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