CD36 (185-1G2), CF647 conjugate, 0.1mg/mL

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Description
Recognizes a protein of 80 kDa-90 kDa, identified as CD36 (Workshop IV; Code P-26) . Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN) . CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Adipocyte membrane protein; CHDS7; Collagen receptor, platelet; fatty acid translocase (FAT) ; Fatty acid transport protein; glycoprotein iiib (GP IIIb) ; PAS IV; PAS-4; pas4 protein; platelet collagen receptor; Platelet glycoprotein 4; scarb3; Scavenger receptor class B member 3; thrombospondin receptor
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CD36
Gene ID
948
NCBI Gene ID
120949
UniProt
P16671
Swiss Prot
P16671
Host
Mouse
Species Reactivity
Human
Reactivity
CD36
Immunogen
Stimulated human leukocytes
Target Antigen
CD36
Clonality
Monoclonal
Clone
185-1G2
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, surface (published) |Functional studies (published) |IF (published) |IP (published)
Field of Research
Immunology, Inflammation
Positive Control
HEL or U937 cells. Platelets, monocytes, macrophages, microvascular endothelial cells in a tonsil.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
80-90 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Blood (2001) 97(6), 1689-1696. (IP) J Biol Chem (2006) 281 (36), 26069-26080. (receptor blockade) J Leukocyte Biol (2014) 95, 509-520. (surface Flow, IF)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2a, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF647
Product Datasheet
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