Cellular Apoptosis Susceptibility Recombinant Rabbit Monoclonal Antibody [JU34-33]

• Description:

  Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin α re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin α and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin α is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.

• Product Name Alternative:

  CAS antibody Cellular apoptosis susceptibility protein antibody Chromosome segregation 1 (yeast homolog) like antibody Chromosome segregation 1 Like antibody Chromosome segregation 1 like protein antibody Chromosome segregation 1-like protein antibody Chromosome segregation gene CSE1 antibody CSE 1 antibody CSE 1 chromosome segregation 1 like antibody CSE 1 chromosome segregation 1 like protein antibody CSE 1L antibody CSE1 antibody CSE1 chromosome segregation 1 like (yeast) antibody CSE1 chromosome segregation 1 like antibody CSE1 chromosome segregation 1 like protein antibody CSE1L antibody Exp 2 antibody Exp2 antibody Exportin 2 antibody Exportin-2 antibody Exportin2 antibody Importin alpha re exporter antibody Importin-alpha re-exporter antibody MGC117283 antibody MGC130036 antibody MGC130037 antibody XPO 2 antibody XPO2 antibody XPO2_HUMAN antibody

• Abbreviation:

  Exp2, CSE1L, CAS, XPO2

• Swiss Prot:

  P55060 Human, Q9ERK4 Mouse

• Cellular Locus:

  Cytoplasm. Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human Cellular Apoptosis Susceptibility aa 860-971 / 971.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IF-Cell, IF-Tissue, IHC-P, FC

• Positive Control:

  SW480 cell lysate, MCF7 cell lysate, SK-Br-3 cell lysate, SiHa cell lysate, PC-3M cell lysate, HeLa cell lysate, Ramos cell lysate, mouse testis tissue lysate, LOVO, PC-3M, SH-SY5Y, human colon carcinoma tissue, mouse testis tissue, LOVO.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;FC: 1:50-1:100

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 110 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3