Mcur1 Rabbit Polyclonal Antibody

• Description:

  Ca2+ flux across the mitochondrial inner membrane regulates bioenergetics, cytoplasmic Ca2+ signals and activation of cell death pathways. Mitochondrial Ca2+ uptake occurs at regions of close apposition with intracellular Ca2+ release sites driven by the inner membrane voltage generated by oxidative phosphorylation and mediated by a Ca2+ selective ion channel called the uniporter. Mitochondrial calcium uniporter (MCU) was recently identified as an ion-conducting pore. MCUR1 (mitochondrial calcium uniporter regulator 1), belongs to the CCDC90 family, an integral membrane protein required for MCU-dependent mitochondrial Ca2+ uptake. MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca2+ uptake. MCUR1 contains two transmembrane helices, where the N- and the short C-termini are exposed to the inter-membrane space. MCUR1 is ubiquitously expressed in mammalian tissues including: skeletal muscle, brain, heart, lung, liver, kidney, large intenstine and spleen. It was found that cells depleted of MCUR1 have abnormal bioenergetic properties similar to those observed in cells in which Ca2+ uptake is blocked. Thus, MCUR1 is necessary for MCU to efficiently promote mitochondrial Ca2+ uptake and to ensure normal mitochondrial bioenergetics.

• Product Name Alternative:

  Mitochondrial calcium uniporter regulator antibody MCU regulator 1 antibody Coiled-coil domain-containing protein 90A, mitochondrial antibody Mcur1 antibody Ccdc90a antibody

• Abbreviation:

  Mitochondrial calcium uniporter regulator MCU regulator 1 Coiled-coil domain-containing protein 90A, mitochondrial Mcur1 Ccdc90a

• Swiss Prot:

  Q9CXD6 Mouse

• Cellular Locus:

  Mitochondrion inner membrane。

• Host:

  Rabbit

• Species Reactivity:

  Mouse

• Immunogen:

  Synthetic peptide within mouse Mcur1 79-128 / 340.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB

• Positive Control:

  Mouse brain tissue lysates.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 38 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4