RBPMS Guinea Pig Polyclonal Antibody

• Description:

  This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly (A) RNA.

• Product Name Alternative:

  RNA-binding protein with multiple splicing Heart and RRM expressed sequence

• Abbreviation:

  RBP-MS, Hermes, RBPMS, HERMES

• Swiss Prot:

  Q93062 Human, Q9WVB0 Mouse

• Cellular Locus:

  Cytoplasm. Nucleus.

• Host:

  Guinea Pig

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide within human RBPMS 1-30 conjugated to Keyhole Limpet Haemocyanin.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Guinea Pig polyclonal Antibody

• Applications:

  WB, ELISA

• Positive Control:

  Ubiquitously expressed, at various levels depending on the isoform and the tissue.

• Concentration:

  1 mg/mL

• Dilution:

  ELISA:1:1,000-1:5,000;WB: 1:500-1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  21 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4