Connexin 45 / GJA7 / Cx45 Rabbit Polyclonal Antibody

• Description:

  Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene. Cx45 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. GJs consist of 3 major connexin (Cx) isoforms—Cx43, Cx40, and Cx45—each of which are characterized by chamber-specific regional distribution and permeation properties. Cx45 is strongly expressed in the early embryonic myocardium and is required for cardiac development (1). Homozygous Cx45-deficient mice are embryonic lethal; however, in the adult heart, Cx45 is expressed mainly at the SA and AV nodes and is not essential for survival of adult mice. Disease-causing mutations in GJ gamma-1 protein (GJC1), which encodes Cx45, have not yet been identified.

• Product Name Alternative:

  Connexin 45 / GJA7 antibody Connexin 45 antibody Connexin-45 antibody Connexin45 antibody CX 31.9 antibody CX 45 antibody CX31.9 antibody Cx45 antibody CXG1_HUMAN antibody DKFZp686P0738 antibody Gap junction alpha 7 protein antibody Gap junction alpha-7 protein antibody Gap junction gamma 1 protein antibody Gap junction gamma-1 protein antibody Gap junction protein alpha 7 45kDa antibody Gap junction protein alpha 7 antibody Gap junction protein, gamma 1, 45kDa antibody GJA 7 antibody GJA7 antibody GJC1 antibody GJD3 antibody

• Abbreviation:

  Cx45, GJC1, GJA7

• Swiss Prot:

  P36383 Human, P28229 Mouse, A4GG66 Rat

• Cellular Locus:

  Cell membrane, Gap junction.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human Connexin 45 aa 257-396 / 396.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P

• Positive Control:

  SH-SY5Y, A431, rat uterus tissue, human liver cancer tissue, human kidney tissue, human placenta tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB:1:500-1:1000 ;IF-Cell:1:500-1:100 ;IHC-P:1:50-1:100

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 45 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4