Acrogranin rabbit pAb

• Background:

  Disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease., function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth., function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling., PTM:Granulins are disulfide bridged., similarity:Belongs to the granulin family., tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

• Description:

  Disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM: 607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. function: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. PTM: Granulins are disulfide bridged. similarity: Belongs to the granulin family. tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

• Synonyms:

  Granulins (Proepithelin;PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]

• Gene ID:

  2896

• UniProt:

  P28799

• Cellular Locus:

  Secreted. Lysosome. Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human Acrogranin AA range: 541-590

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Secreted . Lysosome . Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925) . Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925) . Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity) . .

• Other Product Names:

  Granulins (Proepithelin; PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G) ; Granulin-2 (Granulin F) ; Granulin-3 (Granulin B) ; Granulin-4 (Granulin A) ; Granulin-5 (Granulin C) ; Granulin-6 (Granulin D) ; Granulin-7 (Granulin E) ]

• Gene ID (Human):

  2896

• SwissProt (Human):

  P28799