CD23 (Fc Epsilon RII) (FCER2/3592), CF488A conjugate, 0.1mg/mL

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Description
CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
BLAST-2; C-type lectin domain family 4; member J; CD23; Fc fragment of IgE low affinity II receptor; Fc-epsilon-RII; FCER2; FCER2A; FceRII; IgE-binding factor (IGEBF) ; Immunoglobulin E receptor; low affinity II; Lymphocyte IgE receptor
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
FCER2
Gene ID
2208
NCBI Gene ID
465778
UniProt
P06734
Swiss Prot
P06734
Host
Mouse
Species Reactivity
Human
Reactivity
CD23
Immunogen
Recombinant fragment (around aa 48-321) of human FCER2/CD23 protein (exact sequence is proprietary)
Target Antigen
CD23
Clonality
Monoclonal
Clone
FCER2/3592
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Positive Control
Human lymph node or tonsil (IHC).
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
37 kDa (soluble form) ; 45 kDa (membrane-bound form)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2b, kappa
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF488A
Product Datasheet
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