NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) (NKX3.1/3347), Biotin conjugate, 0.1mg/mL

NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

NK3 Homeobox 1; Homeobox Protein NK-3 Homolog A; NKX3-1; NKX3A; NK3 Transcription Factor Related; Locus 1 (Drosophila) ; NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila) ; Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX3

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

NKX3-1

4824

55999

Q99801

Q99801

NKX3.1

Recombinantfragment (around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)

NKX3.1

NKX3.1/3347

Primary

Animal

Animal

IHC, FFPE (verified)

Highly expressed in the prostate and at a lower level in the testis.

2 years

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

35 kDa

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2b, kappa

0.05% sodium azide (CAS 26628-22-8)