P53 (Tumor Suppressor Protein) (TP53/2719), 0.2mg/mL

The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19, 000, full-length human proteins. Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

Antigen NY-CO-13; BCC7; Cellular Tumor Antigen p53; LFS1; TP53; Transformation Related Protein 53 (TRP53) ; Tumor Protein p53; Tumor Suppressor p53

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

TP53

7157

654481

P04637

P04637

P53

Recombinant human full-length TP53 protein

p53

TP53/2719

Primary

Animal

Animal

IHC, FFPE (verified)

HeLa cells. Colorectal or Ovarian Carcinoma.

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

53 kDa

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2b, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)