Anti-Laminin Receptor / RPSA (Marker of Metastatic Potential)(RPSA/2699), Biotin conjugate

• Description:

  Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  34/67kDa Laminin Receptor; 37kDa Laminin Receptor precursor; 37/67kDa Laminin Receptor; 37LRP; 40S Ribosomal Protein SA; 67kDa Laminin Receptor; 67LR; Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1; Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  RPSA

• Gene ID:

  3921

• NCBI Gene ID:

  449909

• UniProt:

  P08865

• Cellular Locus:

  Plasma membrane|Nucleus & cytoplasm

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant full-length human RPSA protein

• Target Antigen:

  Laminin Receptor | RPSA

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  RPSA/2699

• Conjugation:

  Biotin

• Source:

  Animal

• Applications:

  Flow (verified) | IF (verified)

• Validated Applications:

  FC, IF

• Positive Control:

  MCF-7, MDA-MB-453, SK-BR3, THP1, HL60, HeLa or HEK293 cells. Breast, Colon or Ovarian Carcinoma, Tonsil.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  37-67 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4