Laminin Receptor / RPSA (Marker of Metastatic Potential) (RPSA/2699), CF647 conjugate, 0.1mg/mL

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Description
Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
34/67kDa Laminin Receptor; 37kDa Laminin Receptor precursor; 37/67kDa Laminin Receptor; 37LRP; 40S Ribosomal Protein SA; 67kDa Laminin Receptor; 67LR; Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1; Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
RPSA
Gene ID
3921
NCBI Gene ID
449909
UniProt
P08865
Swiss Prot
P08865
Host
Mouse
Species Reactivity
Human
Reactivity
Laminin Receptor|RPSA
Immunogen
Recombinant full-length human RPSA protein
Target Antigen
Laminin Receptor | RPSA
Clonality
Monoclonal
Clone
RPSA/2699
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow (verified) |IF (verified)
Positive Control
MCF-7, MDA-MB-453, SK-BR3, THP1, HL60, HeLa or HEK293 cells. Breast, Colon or Ovarian Carcinoma, Tonsil.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
37-67 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF647
Product Datasheet
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Product MSDS
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