NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) (NKX3.1/2576), 1mg/mL

CAT: 0037-BNUM2576-50Size: 1x 50 µLDry Ice: NoHazardous: No
CAT#:0037-BNUM2576-50Size:1x 50 µL
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Description
NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
NK3 Homeobox 1; Homeobox Protein NK-3 Homolog A; NKX3-1; NKX3A; NK3 Transcription Factor Related; Locus 1 (Drosophila) ; NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila) ; Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX3
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
NKX3-1
Gene ID
4824
NCBI Gene ID
55999
UniProt
Q99801
Swiss Prot
Q99801
Host
Mouse
Species Reactivity
Human
Reactivity
NKX3.1
Immunogen
Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)
Target Antigen
NKX3.1
Clonality
Monoclonal
Clone
NKX3.1/2576
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Positive Control
Highly expressed in the prostate and at a lower level in the testis.
Stability
2 years
Concentration
1 mg/mL
Buffer
PBS, no BSA, no azide
Molecular Weight
35 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2c, kappa
Species
Mus musculus (mouse)
Classification
PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate
Purified, BSA-free
Product Datasheet
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Product MSDS
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