8-Oxoguanine DNA Glycosylase (CPTC-OGG1-1), CF488A conjugate, 0.1mg/mL

8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

8-oxoguanine DNA glycosylase; HMMH; HOGG1; MUTM; OGH1

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

OGG1

4968

380271

O15527

O15527

N-Glycosylase/DNA lyase

Recombinant full-length human OGG1 protein

N-Glycosylase/DNA lyase

CPTC-OGG1-1

Primary

Animal

Animal

IHC, FFPE (verified)

HeLa or Jurkat cells. Kidney, skin or lymph node.

2 years

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

39 kDa

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Protect from light

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2c, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

0.05% sodium azide (CAS 26628-22-8)