Human IL-33 Recombinant Rabbit Monoclonal Antibody [PSH03-05] - BSA and Azide free (Capture)

• Description:

  Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets.

• Product Name Alternative:

  C9orf26 antibody CHROMOSOME 9 OPEN READING FRAME 26 antibody DKFZp586H0523 antibody DVS27 antibody DVS27 related protein antibody IL 1F11 antibody IL 33 antibody IL-1F11 antibody IL-33 antibody IL1F11 antibody IL33 antibody IL33_HUMAN antibody Interleukin 1 family member 11 antibody Interleukin 33 antibody INTERLEUKIN 33 NFHEV antibody Interleukin 33 precursor antibody Interleukin-1 family member 11 antibody Interleukin-33 (109-270) antibody Interleukin33 antibody NF HEV antibody NF-HEV antibody NFEHEV antibody NFHEV antibody Nuclear factor for high endothelial venules antibody Nuclear factor from high endothelial venules antibody OTTHUMP00000021041 antibody RP11 575C20.2 antibody

• Abbreviation:

  Interleukin-33 IL-33 Interleukin-1 family member 11 (IL-1F11) Nuclear factor from high endothelial venules (NF-HEV) IL33 C9orf26, IL1F11, NFHEV

• Swiss Prot:

  O95760 Human

• Cellular Locus:

  Secreted.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within human IL-33 aa 109-270.

• Isotype:

  IgG

• Clone:

  PSH03-05

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  ELISA (Cap)

• Positive Control:

  Recombinant standard Human Human IL-33 (HA210539).

• Concentration:

  1 mg/mL

• Dilution:

  ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH03-06] to Human Human IL-33 (Detector) (HA721936) and recombinant standard Human Human IL-33 (HA210539) as the standard. The reference range value is 37-1000 pg/ml.

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4).

• Molecular Weight:

  Predicted band size: 30.8 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3