Nucleophosmin Antibody / NPM1

• Description:

  The protein encoded by the NPM1 gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. [RefSeq]

• UniProt:

  P06748

• Host:

  Mouse

• Immunogen:

  A portion of amino acids 185-287 from the human protein was used as the immunogen for the NPM antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

• Reconstitution:

  Store the NPM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This NPM antibody is available for research use only.

• CAS Number:

  9007-83-4