TIMP1 Antibody (N-term) [APR05790G]

• Background:

  Tissue Location: Detected in rheumatoid synovial fluid (at protein level) .

• Synonyms:

  Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP

• Gene Name:

  TIMP1

• Gene ID:

  7076

• UniProt:

  P01033

• Chromosomal Location:

  Secreted

• Applications:

  WB, IHC-P, FC, IF

• Dilution:

  WB--1:1000 IHC-P--1:100~500 FC--1:10~50 IF--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

• Molecular Weight:

  23171

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TIMP1 Antibody (N-term) [APR05790G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=7076

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01033