PLEKHF1 Antibody (N-term) [APR04114G]

• Background:

  Tissue Location: Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.

• Synonyms:

  Pleckstrin homology domain-containing family F member 1, PH domain-containing family F member 1, Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains, Apoptosis-inducing protein, PH and FYVE domain-containing protein 1, Phafin-1, Zinc finger FYVE domain-containing protein 15, PLEKHF1, APPD, LAPF, ZFYVE15

• Gene Name:

  PLEKHF1

• Gene ID:

  79156

• UniProt:

  Q96S99

• Chromosomal Location:

  Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.

• Molecular Weight:

  31195

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PLEKHF1 Antibody (N-term) [APR04114G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=79156

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96S99