MLF1 Antibody (C-term) [APR17812G]

• Background:

  Tissue Location: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes

• Synonyms:

  Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1

• Gene Name:

  MLF1

• Gene ID:

  4291

• UniProt:

  P58340

• Chromosomal Location:

  Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4}

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

• Molecular Weight:

  30627

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MLF1 Antibody (C-term) [APR17812G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4291

• Uniprot URL:

  https://www.uniprot.org/uniprot/P58340