PAX6-T373 Antibody [APR12742G]

• Background:

  Tissue Location: [Isoform 1]: Expressed in lymphoblasts.

• Synonyms:

  Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2

• Gene Name:

  PAX6

• Gene ID:

  5080

• UniProt:

  P26367

• Chromosomal Location:

  Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}

• Applications:

  WB, IHC-P, IF

• Dilution:

  WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity) .

• Molecular Weight:

  46683

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PAX6-T373 Antibody [APR12742G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5080

• Uniprot URL:

  https://www.uniprot.org/uniprot/P26367