E2F8 Antibody (C-Term) [APR07631G]

• Synonyms:

  Transcription factor E2F8, E2F-8, E2F8

• Gene Name:

  E2F8

• Gene ID:

  79733

• UniProt:

  A0AVK6

• Chromosomal Location:

  Nucleus.

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3) . Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

• Molecular Weight:

  94166

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality E2F8 Antibody (C-Term) [APR07631G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=79733

• Uniprot URL:

  https://www.uniprot.org/uniprot/A0AVK6