MAPT Antibody (C-term) [AMM06339G]

• Background:

  Tissue Location: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system

• Synonyms:

  Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU

• Gene Name:

  HGNC:6893

• Gene ID:

  4137

• UniProt:

  P10636

• Chromosomal Location:

  Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907) . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059) .

• Applications:

  WB

• Dilution:

  WB--1:500 WB--1:1000

• Function:

  219853112198531132961270

• Molecular Weight:

  78928

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAPT Antibody (C-term) [AMM06339G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4137

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10636