Thymidine 5′-monophosphate p-nitrophenyl ester (sodium)

• UNSPSC Description:

  Thymidine 5′-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5′-monophosphate p-nitrophenyl ester sodium penetrates mammalian cells, releases intracellular antimetabolite 5' nucleotides. Thymidine 5′-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thymidine-5-monophosphate-p-nitrophenyl-ester-sodium.html

• Smiles:

  O=C(N1)N([C@@H]2O[C@H](COP(OC3=CC=C([N+]([O-])=O)C=C3)(O[Na])=O)[C@@H](O)C2)C=C(C)C1=O

• Molecular Weight:

  465.28

• References & Citations:

  [1]Chawla RR, et al., Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in mouse cells in culture. J Med Chem. 1984 Dec;27(12):1733-6.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  98179-10-3