Anti-NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) ENO2 Monoclonal Antibody

• Background:

  Recognizes a protein of about 50kDa, which is identified as gamma-enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas.It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.

• Description:

  Boster Bio Anti-NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) ENO2 Monoclonal Antibody (Catalog # M02930) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Gamma-enolase;4.2.1.11;2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE; ENO2

• Gene Name:

  ENO2

• UniProt:

  P09104

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human NSE gamma (around aa416-433) (exact sequence is proprietary)

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: ENO2/1375

• Tissue Specificity:

  The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

• Applications:

  WB, IHC

• Field of Research:

  Cancer, Cancer Metabolism, Carbohydrate Metabolism, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Signal Transduction, Transcription, Tumor Biomarkers

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) . .

• Molecular Weight:

  47269 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG2b, kappa

• Other Gene Names:

  Gamma-enolase

• Subcellular Location:

  Cytoplasmic