Anti-Fragilis IFITM3 Monoclonal Antibody

• Description:

  Boster Bio Anti-Fragilis IFITM3 Monoclonal Antibody catalog # M02265. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; ARNT; BHLHE2

• Gene Name:

  Aryl hydrocarbon receptor nuclear translocator

• UniProt:

  Q01628

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human Fragilis

• Clonality:

  Monoclonal

• Clone:

  Clone: ADAC-9

• Tissue Specificity:

  Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. .

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry

• Field of Research:

  Developmental Biology, Germ Cell Markers, Germline Stem Cells, Reproduction, Stem Cells

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  FC 1:50

• Other Gene Names:

  IFITM3

• Subcellular Location:

  Nucleus.

• Protein Name:

  Lysosome-associated membrane glycoprotein 2 (Lamp2)